Endocrine Abstracts

Introduction: Intraoperative quick PTH (iqPTH) monitoring is important in the treatment of primary hyperparathyroidism (pHPTH), allowing, together with preoperative localisation, the switch from routine bilateral neck exploration to limited gland excision.Aims: We checked the advantage of iqPTH for improving the cure rate of patients operated for pHPTH by using minimally invasive surgery (MIS).Materials and methods: Retrospective s...

Hashimoto’s thyroiditis is an autoimmnune condition most common in females but can be also found in children with a prevalence of 1.2%. When is associated with hypothyroidism, the growth delay is an important, but late symptom. We present the case of a 12-year-old boy presenting with small height for age (123 cm, <−3 S.D.), important weight gain and fatigue. He was the only child from parents of average height and had normal weight at birth (3300 ...

Introduction: High-resolution ultrasound (US) allows the location of large parathyroid adenomas. These tumours should be however differentiated from thyroid nodules. For the confirmation of the parathyroid adenoma, we propose US-guided fine-needle aspiration biopsy (FNAB) of suspected nodules, with additional parathyroid hormone (PTH) analysis in the washout of the aspirate (PTH-FNA).Case report: A 51-year old woman with recently installed menopause and ...

Introduction: Graves’ disease (GD) has been related to a higher incidence of thyroid cancer. Thyroid nodules found in GD seem to have a higher risk for malignancy. The prognosis of thyroid cancer may be aggravated by the association with GD.Case report: We present the case of N.I, a 56-year-old woman diagnosed with multinodular goitre and overt hyperthyroidism for which therapy with carbimazole 40 mg/day was started. She was referred to our Endocrin...

Introduction: Idiopathic hypercalciuria is a risk factor for nephrolithiasis. Both renal stones and hypercalciuria are often associated with lower bone mineral density (BMD), but the relationship between these modifications is not completely understood. We aimed to evaluate some metabolic particularities possibly related to relapsing nephrolithiasis in young male patients.Methods: We performed a cross-sectional study including a group of 30 young male pa...

Published data regarding the role of FGF23 in primary hyperparathyroidism and its prognostic applicability are scarce and discordant.Aims: To assess FGF23 profile in patients with primary hyperparathyroidism undergoing surgery.Matherials and methods: Longitudinal study involving 48 patients aged 30–80 years with primary hyperparathyroidism caused by solitary parathyroid adenoma, submitted to parathyroidectomy. We evaluated FGF...

Background: Vitamin D deficiency is frequently associated with primary hyperparathyroidism, but the impact of this association on disease evolution and complications is ill defined. Aims: to assess the role of vitamin D status on the metabolic profile and spectrum of complications at patients with primary hyperparathyroidism.Materials and methods: Transversal study involving 42 patients with primary hyperparathyroidism submitted to parathyroidectomy. We ...

Background: D hypovitaminosis and primary hyperparathyroidism frequently coexist. Secondary hyperparathyroidism reactive to D hypovitaminosis is difficult to be differentiated from primary hyperparthyroidism.Aims: To differentiate patients with D hypovitaminosis and secondary hyperparathyroidism.Materials and methods: Prospective study involving 71 patients admitted in our department for 1 year with the initial diagnosis of primary...

Aim: Fibroblast growth factor-23 (FGF-23) has been proposed as a predictor of bone abnormalities in chronic kidney disease patients (CKD), with recent data showing that it may also predict bone mass in the general population. We aimed at investigating the relationship between FGF-23 and bone mass parameters in apparently healthy individuals, according to sex, menopausal and nutritional status.Materials and methods: Bone mass (bone mineral density-BMD, bo...

Introduction: Despite the high burden of osteoporotic fractures, bone evaluation in men is not without flaws, being frequently undervalued. We aimed at investigating the role of body composition, adipokines and classic bone determinants (sex hormones) as predictive factors for bone mass parameters in healthy young and middle-aged men.Materials and methods: Anthropometric, bone mineral density (BMD) (assessed by Dual X-Ray Absorptiometry;DXA) and body com...